use sudo to run as root.
then use this command
#!/bin/zsh
if [ -d "/Applications/Microsoft Defender.app" ]; then
if [ -e "/Library/Application Support/Microsoft/Defender/uninstall/uninstall" ]; then
/bin/echo "Using the uninstall option to remove Defender and any support files..."
"/Library/Application Support/Microsoft/Defender/uninstall/uninstall"
else
/bin/echo "Deleting the Microsoft Defender shim from Applications..."
/bin/rm -Rfd "/Applications/Microsoft Defender.app"
fi
else
/bin/echo "Microsoft Defender shim is not installed on this Mac."
fi